A NEW, HIGHLY POTENT, HEPARIN-LIKE PENTASACCHARIDE FRAGMENT CONTAINING A GLUCOSE RESIDUE INSTEAD OF A GLUCOSAMINE

被引：37

作者：

PETITOU, M

JAURAND, G

DERRIEN, M

DUCHAUSSOY, P

CHOAY, J

机构：

[1] Sanofi Recherche-Centre Choay, 94256 Gentilly Cedex

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)80238-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis is reported of a new heparin-like pentasaccharide fragment in which the reducing end glucosamine unit is replaced by a glucose residue. This indicates that an O-sulfate can be substituted for a N-sulfate thereby allowing simpler synthesis of this kind of compounds. A new route using a trisaccharide imidate as glycosyl donor was developed for this preparation.

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页码：95 / 98

页数：4

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