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A TEST OF THE SPINE RESISTANCE HYPOTHESIS FOR LTP EXPRESSION

被引：14
作者：
LARSON, J
LYNCH, G
机构：
[1] Center for the Neurobiology of Learning and Memory, University of California, Irvine
来源：
BRAIN RESEARCH | 1991年 / 538卷 / 02期
关键词：
LONG-TERM POTENTIATION; DENDRITIC SPINE; V-METHYL-D-ASPARTATE RECEPTOR; QUISQUALATE RECEPTOR; TEMPERATURE; CA1; HIPPOCAMPUS;
D O I：
10.1016/0006-8993(91)90454-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Long-term potentiation (LTP) consists of an enhanced response to release transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines would selectively augment fast synaptic currents and this could produce the pattern of results found with LTP. The present experiments tested this hypothesis by asking whether non-NMDA responses slowed by low temperature to resemble NMDA responses could express LTP. Slow non-NMDA responses recorded at 25-degrees-C did express LTP, indicating that the time courses of NMDA responses cannot explain why they do not express LTP. The results, therefore, do not support the hypothesis that spine resistance changes are responsible for the enhanced transmission.
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收藏
页码：347 / 350
页数：4
相关论文
共 26 条
[1]   CONDUCTANCE MECHANISM RESPONSIBLE FOR LONG-TERM POTENTIATION IN MONO-SYNAPTIC AND ISOLATED EXCITATORY SYNAPTIC INPUTS TO HIPPOCAMPUS [J].
BARRIONUEVO, G ;
KELSO, SR ;
JOHNSTON, D ;
BROWN, TH .
JOURNAL OF NEUROPHYSIOLOGY, 1986, 55 (03) :540-550
[2]  
BROWN T H, 1988, P201
[3]   TRANSIENT AND ENDURING MORPHOLOGICAL CORRELATES OF SYNAPTIC ACTIVITY AND EFFICACY CHANGE IN THE RAT HIPPOCAMPAL SLICE [J].
CHANG, FLF ;
GREENOUGH, WT .
BRAIN RESEARCH, 1984, 309 (01) :35-46
[4]   DEPENDENCE ON TEMPERATURE OF CONDUCTION VELOCITY OF ACTION POTENTIAL OF SQUID GIANT AXON [J].
CHAPMAN, RA .
NATURE, 1967, 213 (5081) :1143-&
[5]  
COLLINGRIDGE GL, 1988, J PHYSIOL-LONDON, V399, P301
[6]   EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].
COLLINGRIDGE, GL ;
KEHL, SJ ;
MCLENNAN, H .
JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46
[7]   THE FUNCTION OF DENDRITIC SPINES - A REVIEW OF THEORETICAL ISSUES [J].
COSS, RG .
BEHAVIORAL AND NEURAL BIOLOGY, 1985, 44 (02) :151-185
[8]   CHANGES IN THE NUMERICAL DENSITY OF SYNAPTIC CONTACTS WITH LONG-TERM POTENTIATION IN THE HIPPOCAMPAL DENTATE GYRUS [J].
DESMOND, NL ;
LEVY, WB .
JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 253 (04) :466-475
[9]   SLOW EXCITATORY POSTSYNAPTIC CURRENTS MEDIATED BY N-METHYL-D-ASPARTATE RECEPTORS ON CULTURED MOUSE CENTRAL NEURONS [J].
FORSYTHE, ID ;
WESTBROOK, GL .
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 396 :515-533
[10]   LONG-TERM POTENTIATION IN THE HIPPOCAMPUS INVOLVES ACTIVATION OF N-METHYL-D-ASPARTATE RECEPTORS [J].
HARRIS, EW ;
GANONG, AH ;
COTMAN, CW .
BRAIN RESEARCH, 1984, 323 (01) :132-137
123