PRECURSOR AND DEAMINATED FORMS OF BOTH LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH) AND (HYDROXYPROLINE9)LHRH ARE PRESENT IN THE RAT HYPOTHALAMUS

被引：10

作者：

GAUTRON, JP

PATTOU, E

KORDON, C

机构：

[1] Unité INSERM 159 de Dynamique, Systèmes Neuroendocriniens Centre Paul Broca, 75014 Paris, 2 ter, rue d'Alésia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90225-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A naturally occuring analog of the decapeptide luteinizing hormone-releasing hormone ([Hyp9]LHRH) has been described previously in the hypothalamus of several mammals. It derives from post-translational hydroxylation of the LHRH proline9 residue. In the present work, intermediate LHRH precursors exhibiting both Pro9 or Hyp9 residues in the LHRH sequence were characterized in the rat hypothalamus. Hydroxylation of the Pro9 residue can thus be assumed to occur at an early stage of post-translational maturation. Deaminated, free acid forms of both native decapeptides were also detected. They correspond most likely to catabolites from incompletely processed precursors. © 1992.

引用

页码：1368 / 1373

页数：6

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