DETERMINATION OF AMITRIPTYLINE, IMIPRAMINE AND ORPHENADRINE IN ANTIDEPRESSANT DRUGS BY POTENTIOMETRY, SPECTROPHOTOMETRY AND ATOMIC-ABSORPTION SPECTROMETRY

被引:48
作者
ELNEMMA, EM
ELZAWAWY, FM
HASSAN, SSM
机构
[1] AIN SHAMS UNIV,FAC SCI,DEPT CHEM,CAIRO,EGYPT
[2] QATAR UNIV,FAC SCI,DEPT CHEM,DOHA,QATAR
关键词
REINECKATES; ANTIDEPRESSANT DRUGS; ATOMIC ABSORPTION SPECTROMETRY; SPECTROPHOTOMETRY; LIQUID MEMBRANE ELECTRODES; AMITRIPTYLINE; IMIPRAMINE; ORPHENADRINE;
D O I
10.1007/BF01243988
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Methods are described for the determination of amitriptyline, imipramine and orphenadrine in some antidepressant drugs. They are based on a prior reaction with ammonium reineckate to form 1 : 1 water-insoluble drug-reineckate ion-pair complexes. These complexes are (1) used an ion-exchangers in liquid-membrane electrodes responsive to the drug cations, (ii) extracted with nitrobenzene or dissolved in acetonitrile and spectrophotometrically measured at 525 nm and (iii) dissolved in 90% acetone followed by nebulization in an air-acetylene flame for atomic absorption spectrometric measurements of Cr at 358.6 nm. The reaction and monitoring conditions are optimized to permit determination of as little as 10 mug/ml of the drugs. Determination of the drugs in some pharmaceutical preparations shows an average recovery of 98.8% of the nominal and a mean standard deviation of 0.8%. The results compare favorably with data obtained by the United States and British Pharmacopoeia methods.
引用
收藏
页码:79 / 88
页数:10
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