LOCALIZATION OF THE TAMM-HORSFALL GLYCOPROTEIN (UROMODULIN) GENE TO CHROMOSOME 16P12.3-16P13.11

被引：32

作者：

POOK, MA

JEREMIAH, S

SCHEINMAN, SJ

POVEY, S

THAKKER, RV

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,MRC,MOLEC MED GRP,LONDON W12 0NN,ENGLAND

[2] MRC,HUMAN BIOMED GENET UNIT,GALTON LAB,LONDON NW1 2HE,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1993年 / 57卷

关键词：

D O I：

10.1111/j.1469-1809.1993.tb00902.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mapping studies using a panel of 22 rodent-human somatic cell hybrids have helped to localize the Tamm-Horsfall glycoprotein (uromodulin) gene (UMOD), which has previously been reported to map to 16p13.11, to the region 16p12.3-qter. The combined results indicate that U;MOD is located distal to D16S295 and proximal to D16S287 and in the region 16p12.3-16p13.11. Uromodulin is known to affect the formation of calcium-containing kidney stones, and this localization of UMOD will help in studies of families with autosomal forms of nephrolithiasis.

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页码：285 / 290

页数：6

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