INDUCTION OF TRANSFORMING GROWTH-FACTOR-BETA IN HORMONALLY TREATED HUMAN PROSTATE-CANCER

被引:36
作者
MUIR, GH
BUTTA, A
SHEARER, RJ
FISHER, C
DEARNALEY, DP
FLANDERS, KC
SPORN, MB
COLLETTA, AA
机构
[1] INST CANC RES,HARTWELL LAB,ACAD SURG SECT,LONDON SW3 6JJ,ENGLAND
[2] ROYAL MARSDEN HOSP,LONDON SW3 6JJ,ENGLAND
[3] NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892
关键词
D O I
10.1038/bjc.1994.21
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Transforming growth factor beta-1 (TGF-beta 1) has been proposed as a mediator of tumour growth in a number of tumours and cell lines including prostate, and in a recent study was shown to be up-regulated in the stroma of breast cancer tissue following treatment with the anti-oestrogen tamoxifen. Immunolocalisation of the intracellular form of TGF-beta 1 confirmed that the source of the stromal TGF-beta 1 was the peritumoral fibroblasts. We present here the results of a study in which five patients with hormonally unresponsive prostatic carcinoma and seven patients responding to a luteinising hormone-releasing hormone analogue had prostate biopsies taken before and during treatment. These were stained for TGF-beta expression prior to treatment and at either relapse or 3 months later respectively. Six of seven clinically responding tumours and three of five relapsed tumours showed up-regulation of extracellular TGF-beta 1, again primarily in the stroma, with no apparent up-regulation of intracellular TGF-beta 1, TGF-beta 2 or TGF-beta 3. These data illustrate that the epithelial growth inhibitor TGF-beta 1 can be induced by hormonal manipulation in prostate cancer in vivo, and may continue to be up-regulated even after relapse. This suggests that relapse of hormonally treated prostate cancer may be associated with a failure of the epithelium to respond to stromal TGF-beta 1.
引用
收藏
页码:130 / 134
页数:5
相关论文
共 25 条
[1]  
BUTTA A, 1992, CANCER RES, V52, P4261
[2]   THE GROWTH-INHIBITION OF HUMAN BREAST-CANCER CELLS BY A NOVEL SYNTHETIC PROGESTIN INVOLVES THE INDUCTION OF TRANSFORMING GROWTH-FACTOR-BETA [J].
COLLETTA, AA ;
WAKEFIELD, LM ;
HOWELL, FV ;
DANIELPOUR, D ;
BAUM, M ;
SPORN, MB .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (01) :277-283
[3]  
COLLETTA AA, 1991, FEBS LETT, V291, P132
[4]  
Cunha G R, 1987, Prog Clin Biol Res, V239, P251
[5]  
CUNHA GR, 1990, CURRENT CONCEPTS APP, P251
[6]   TRANSFORMING GROWTH FACTOR-BETA-1 - HISTOCHEMICAL-LOCALIZATION WITH ANTIBODIES TO DIFFERENT EPITOPES [J].
FLANDERS, KC ;
THOMPSON, NL ;
CISSEL, DS ;
VANOBBERGHENSCHILLING, E ;
BAKER, CC ;
KASS, ME ;
ELLINGSWORTH, LR ;
ROBERTS, AB ;
SPORN, MB .
JOURNAL OF CELL BIOLOGY, 1989, 108 (02) :653-660
[7]   PROGNOSTIC FACTORS IN HORMONE-RESISTANT PROGRESSING CANCER OF THE PROSTATE [J].
FOSSA, SD ;
DEARNALEY, DP ;
LAW, M ;
GAD, J ;
NEWLING, DWW ;
TVETER, K .
ANNALS OF ONCOLOGY, 1992, 3 (05) :361-366
[8]  
GLICK AB, 1991, DEVELOPMENT, V111, P1081
[9]   EFFECTS OF INTERFERON BETA-SER AND TRANSFORMING GROWTH-FACTOR-BETA ON PROSTATIC CELL-LINES [J].
GOLDSTEIN, D ;
OLEARY, M ;
MITCHEN, J ;
BORDEN, EC ;
WILDING, G .
JOURNAL OF UROLOGY, 1991, 146 (04) :1173-1177
[10]   ORCHIECTOMY VERSUS ESTROGEN FOR PROSTATIC-CANCER - CARDIOVASCULAR EFFECTS [J].
HENRIKSSON, P ;
EDHAG, O .
BRITISH MEDICAL JOURNAL, 1986, 293 (6544) :413-415