ELECTROPHYSIOLOGICAL EVIDENCE FOR THE ANTINOCICEPTIVE EFFECT OF TRANSCUTANEOUS ELECTRICAL-STIMULATION ON MECHANICALLY EVOKED RESPONSIVENESS OF DORSAL HORN NEURONS IN NEUROPATHIC RATS

被引：50

作者：

LEEM, JW

PARK, ES

PAIK, KS

机构：

[1] Department of Physiology, Yonsei University College of Medicine, Seoul, 120-752

来源：

NEUROSCIENCE LETTERS | 1995年 / 192卷 / 03期

关键词：

NEUROPATHY; PAIN; ALLODYNIA; HYPERALGESIA; ANALGESIA; ELECTROACUPUNCTURE; WIDE DYNAMIC RANGE; SPINAL CORD;

D O I：

10.1016/0304-3940(95)11644-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using a rat model of peripheral neuropathy induced by a tight ligation of L5-6 spinal nerves, the effects of transcutaneous electrical stimulation on the mechanical responses of wide dynamic range (WDR) dorsal horn neurons were investigated. The responses of the WDR neurons to both the brush and pinch stimuli were found to be enhanced in the neuropathic rats compared to those in the normal rats. These enhanced responses were depressed by low-frequency and high-intensity transcutaneous electrical stimulation (2 Hz, 4-5 mA) applied to the somatic receptive field. The durations of the depressive effects on the brush responses ranged between 30 and 45 min and those on the pinch responses were 60-90 min. These results imply that the transcutaneous electrical stimulation used here produces an antinociceptive effect via a depressive action on the enhanced mechanical responsiveness of the spinal neurons in this rat model of peripheral neuropathy.

引用

页码：197 / 200

页数：4

共 22 条

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