MODULATION OF GRANULOMA-FORMATION BY ENDOGENOUS NITRIC-OXIDE

被引：51

作者：

IUVONE, T

CARNUCCIO, R

DIROSA, M

机构：

[1] Department of Experimental Pharmacology, University of Naples Federico II, 80132 Naples, Via D. Montesano

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 265卷 / 1-2期

关键词：

GRANULOMA; NITRIC OXIDE (NO); L-ARGININE; N-G-NITRO-L-ARGININE METHYL ESTER; MACROPHAGE;

D O I：

10.1016/0014-2999(94)90227-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have studied the possible involvement of nitric oxide (NO) in granuloma formation induced by subcutaneous implantation in rats of carrageenin-soaked polyether sponges. Modulation of the L-arginine:NO pathway in rats was achieved by treating rats with the NO synthase inhibitor, N-G-nitro-L-arginine methyl ester, as well as with L- or D-arginine. Granulomatous tissue formation, cell infiltration and NO2- production were reduced, in a dose-dependent manner, by N-G-nitro-L-arginine methyl ester and increased by L-arginine but not by D-arginine. These results suggest that endogenous NO plays a modulating role in granuloma formation.

引用

页码：89 / 92

页数：4

共 15 条

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