STUDY OF THE SELF-ASSOCIATION OF METHYLATED PYRIMIDINES IN AQUEOUS-SOLUTIONS BY H-1-NMR CHEMICAL-SHIFTS

被引：9

作者：

ARADI, F

机构：

[1] Central Laboratory, University Medical School, Pecs, H-7624

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1990年 / 28卷 / 03期

关键词：

!sup]1[!/sup]H NMR chemical shift; Methylation; Pyrimidine; Self‐association; Stacking;

D O I：

10.1002/mrc.1260280310

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The self‐association of pyrimidine and its methylated derivatives was studied by measuring the concentration‐dependent changes in proton chemical shifts in deuterium oxide at 35°C. The data were analysed by a dimer model with two parameters. The equilibrium constants give an increasing tendency for self‐association within the series pyrimidine (0.091 ° 0.006 l mol−1) < 5‐methylpyrimidine (0.165 ° 0.006 l mol−1) ≈ 4‐methylpyrimidine (0.183 ± 0.005 l mol−1) < 4,6‐dimethylpyrimidine (0.410 ± 0.011 l mol−1), and the values of the dimer shifts suggest a stacking‐like arrangement for the associated molecules. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：246 / 249

页数：4

共 52 条

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