N-CYANOINDOLES AND N-CYANOINDOLE-4,7-DIONES - CONSTRUCTION OF A BC RING SYNTHON FOR THE KINAMYCINS

被引：26

作者：

DMITRIENKO, GI

NIELSEN, KE

STEINGART, C

MING, NS

WILLSON, JM

WEERATUNGA, G

机构：

[1] Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Waterloo, Waterloo, Ont. N2L 3G1, Waterloo Campus

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)97443-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Cyano-2,3-dialkylindoles, available by reaction of N-sodioindoles with phenyl cyanate, are substantially less reactive than N-acylindoles under electrophilic bromination conditions but readily yield sidechain brominated products under free radical conditions. Ceric ammonium nitrate oxidation of N-cyano-4,7-dimethoxy-2,3-disubstituted indoles yields the corresponding N-cyanoindole-4,7-diones which are potentially synthons for construction of kinamycins, 1. © 1990.

引用

页码：3681 / 3684

页数：4

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