TREATMENT OF HAY-FEVER WITH LORATADINE - A NEW NON-SEDATING ANTIHISTAMINE

被引：11

作者：

IRANDER, K ^{[1
]}

ODKVIST, LM ^{[1
]}

OHLANDER, B ^{[1
]}

机构：

[1] VAXJO HOSP,DEPT OTOLARYNGOL,VAXJO,SWEDEN

来源：

ALLERGY | 1990年 / 45卷 / 02期

关键词：

allergic rhino‐conjunctivitis; clemastine; loratadine; seasonal allergy;

D O I：

10.1111/j.1398-9995.1990.tb00463.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The efficacy and safety of loratadine, a new orally active specific H‐receptor blocking antihistamine with poor penetration into the CNS, was evaluated in a double blind comparative study. One hundred and seven hay fever patients, sensitive to birch pollen, were randomized into three parallel groups receiving loratadine 40 mg once daily, clemastine 1 mg twice daily, or placebo during the birch pollen season. Both active treatments showed reduction of symptoms in comparison with placebo, but the results were more pronounced with loratadine treatment, which significantly reduced the overall allergic condition as well as all separate allergic rhino‐conjunctivitis symptoms except nasal stuffiness. Compared with placebo the sedation rate was significantly higher with clemastine treatment (P < 0.05) but not with loratadine, Loratadine was thus concluded to be efficacious in hay fever treatment with a sedation rate not differing from placebo. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：86 / 91

页数：6

共 23 条

[1] SELECTIVE DISPLACEMENT OF [H-3] MEPYRAMINE FROM PERIPHERAL VS CENTRAL-NERVOUS-SYSTEM RECEPTORS BY LORATADINE, A NONSEDATING ANTIHISTAMINE [J].