SERUM LEVELS OF CA-125 DURING THE 1ST TRIMESTER OF NORMAL OUTCOME, ECTOPIC AND ANEMBRYONIC PREGNANCIES

被引：15

作者：

JACOBS, IJ ^{[1
]}

FAY, TN ^{[1
]}

YOVICH, J ^{[1
]}

STABILE, I ^{[1
]}

FROST, C ^{[1
]}

TURNER, J ^{[1
]}

ORAM, DH ^{[1
]}

GRUDZINSKAS, JG ^{[1
]}

机构：

[1] LONDON HOSP,COLL MED,ACAD UNIT OBSTET & GYNAECOL,LONDON E1 1BB,ENGLAND

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 01期

关键词：

CA; 125; Pregnancy;

D O I：

10.1093/oxfordjournals.humrep.a137030

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Single serum samples were obtained during the first trimester of pregnancies with a retrospectively normal outcome (n = 150), ectopic pregnancies (n = 38) and anembryonic pregnancies (n = 78). Serial samples during the first trimester were also obtained from 43 women achieving pregnancy following successful treatment for infertility and with a retrospectively defined normal outcome. Significant variation in serum CA 125 levels in relation to gestational age was observed in pregnancies with a normal outcome (P > 0.0001). Peak serum CA 125 levels were observed at 6-7 weeks, the mean level at this gestation being 40.1 U/ml (range 31.7-50.7 U/ml) in the normal conception/normal outcome group and 36.5 U/ml (range 25.6-52.0 U/ml) in the assisted conception/normal outcome group. A rise and fall in serum CA 125 levels during the first trimester was observed in 42 of 43 assisted conceptions monitored serially, with peak levels ranging from 7 to 1398 U/ml (median 48.8 U/ml) occurring at 28-61 days (median 45 days) gestation. Mean serum CA 125 levels were higher in the anembryonic pregnancy group at 4-5 and 6-7 weeks gestation than in both normal pregnancy outcome groups (P > 0.01). © 1990 Oxford University Press.

引用

页码：116 / 122

页数：7

共 25 条

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