SKIN MICROCIRCULATION AND REGIONAL PERIPHERAL RESISTANCE IN PATIENTS WITH CHRONIC RENAL ANEMIA TREATED WITH RECOMBINANT-HUMAN-ERYTHROPOIETIN

被引：16

作者：

CREUTZIG, A ^{[1
]}

CASPARY, L ^{[1
]}

NONNASTDANIEL, B ^{[1
]}

BAHLMANN, J ^{[1
]}

KUHN, K ^{[1
]}

BRUNKHORST, R ^{[1
]}

REIMERS, E ^{[1
]}

KOCH, KM ^{[1
]}

ALEXANDER, K ^{[1
]}

机构：

[1] HANOVER MED SCH, DEPT NEPHROL, W-3000 Hannover 61, GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1990年 / 20卷 / 02期

关键词：

Chronic renal anaemia; recombinant human erythropoietin; regional peripheral resistance; transcutaneous Po[!sub]2[!/sub; vasoconstrictor response;

D O I：

10.1111/j.1365-2362.1990.tb02272.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Skin microcirculation and regional peripheral resistance were studied in 14 patients with renal anaemia during therapy with recombinant human erythropoietin. Haematocrit was raised from 20·0 to 31·3% after 10–12 weeks of treatment and remained stable over another period of 12 weeks. Antihypertensive treatment had to be intensified in five patients. Regional calf blood flow decreased significantly; accordingly, calculated peripheral vascular resistance was increased by more than 100%. However, transcutaneous oxygen pressure (37°C and 44°C) increased significantly. The pathological vasoconstrictor response of skin capillaries was not influenced. There were no significant differences of any parameter between the patients requiring reinforced antihypertensive therapy and those with stable blood pressure. In conclusion skin oxygenation may be improved by erythropoietin treatment to a large extent despite an increase in calculated total limb vascular resistance. 1990 European Society for Clinical Investigation

引用

页码：219 / 223

页数：5

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