ARE CHROMOSOME-ABERRATIONS IN CIRCULATING LYMPHOCYTES PREDICTIVE OF FUTURE CANCER ONSET IN HUMANS - PRELIMINARY-RESULTS OF AN ITALIAN COHORT STUDY

被引：269

作者：

BONASSI, S

ABBONDANDOLO, A

CAMURRI, L

DALPRA, L

DEFERRARI, M

DEGRASSI, F

FORNI, A

LAMBERTI, L

LANDO, C

PADOVANI, P

SBRANA, I

VECCHIO, D

PUNTONI, R

机构：

[1] IST NAZL RIC CANC,MUTAGENESI LAB,I-16132 GENOA,ITALY

[2] CSTA,GENOA,ITALY

[3] LAB GENET,USL 9,REGGIO EMILIA,ITALY

[4] UNIV MILAN,CLIN OSTET & GINECOL 1,CITOGENET LAB,MILAN,ITALY

[5] UNIV ROMA LA SAPIENZA,DIPARTIMENTO GENET & BIOL MOLEC,ROME,ITALY

[6] UNIV MILAN,CLIN LAVORO L DEVOTO,IST MED LAVORO,MILAN,ITALY

[7] UNIV TURIN,DIPARTIMENTO BIOL ANIM,ANTROPOL LAB,I-10123 TURIN,ITALY

[8] UNIV PISA,DIPARTIMENTO SCI AMBIENTE & TERR,I-56100 PISA,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 79卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)00131-T

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the lost 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.

引用

页码：133 / 135

页数：3

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