EFFECT OF MEMBRANE POLARIZATION ON TIME COURSE OF END-PLATE CURRENT IN FROG SARTORIUS MUSCLE

1. Intracellular recordings of the end‐plate current at different membrane potentials were made, using a voltage‐clamp technique. 2. When the membrane potential is varied between about +40 and −120 mV, the half‐decline time of the end‐plate current increases from about 0·6 msec to about 1·6 msec. 3. It is suggested that the stability of receptor—mediator complex is affected by the membrane potential. © 1969 The Physiological Society