IGG SUBCLASS, VARIABLE H-CHAIN SUBGROUP, AND LIGHT CHAIN-TYPE COMPOSITION OF ANTINEURONAL ANTIBODY IN HUNTINGTONS-DISEASE AND SYDENHAMS CHOREA

Antineuronal antibodies from patients with Huntington's Disease and Sydenham's chorea were analyzed for the IgG subclass, light chain type, and VH subgroup composition, using specific antisera against the various antigens in indirect immunofluorescent technique. The antineuronal antibodies were heterogeneous and showed little restriction to the parameters tested for, except for the antineuronal antibodies from patients with Huntington's Disease which in 8 of 10 cases were restricted to one light chain type. In 6 of these the antibodies belonged exclusively to the λ light chain type. The results indicate that the neuronal antibodies may be directly against different antigenic determinants. © 1979.