TESTOSTERONE 5ALPHA-REDUCTASE AND THE ACCUMULATION OF DIHYDROTESTOSTERONE IN BENIGN PROSTATIC HYPERPLASIA

被引：18

作者：

COWAN, RA

COOK, B

COWAN, SK

GRANT, JK

SIRETT, DAN

WALLACE, AM

机构：

[1] University Department of Pathological Biochemistry, Royal Infirmary, Glasgow

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1979年 / 11卷 / 01期

关键词：

D O I：

10.1016/0022-4731(79)90089-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human benign hyperplastic prostate was separated mechanically into epithelial and stromal components. The recovery and relative enrichment of these separated tissues was assessed with biochemical markers. Testosterone 5α-reductase showed a predominantly stromal location, but the distribution of endogenous 5α-dihydrotestosterone (DHT) did not parallel that of the reductase. The concentration of steroid was greater in the epithelial fraction although substantial amounts were associated with the stromal preparation. In subcellular fractions of whole homogenate, DHT showed greatest affinity for the microsomal fraction. © 1979.

引用

页码：609 / 613

页数：5

共 17 条

[1] PROSTATE CONCENTRATIONS OF ENDOGENOUS ANDROGENS BY RADIOIMMUNOASSAY [J].