THE BASIS FOR CHOICE REACTION-TIME SLOWING IN ALZHEIMERS-DISEASE

被引：74

作者：

GORDON, B

CARSON, K

机构：

[1] JOHNS HOPKINS UNIV,DIV COGNIT NEUROL,BALTIMORE,MD 21218

[2] JOHNS HOPKINS UNIV,DEPT PSYCHOL,BALTIMORE,MD 21218

[3] JOHNS HOPKINS UNIV,DEPT NEUROL,BALTIMORE,MD 21218

来源：

BRAIN AND COGNITION | 1990年 / 13卷 / 02期

关键词：

D O I：

10.1016/0278-2626(90)90047-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Slowed reaction time has been suggested as an early feature of Alzheimer's disease (AD), but the basis for this slowing has not been established. Patients with mild AD were compared with controls on a choice reaction time task, both cued (CCRT) and uncued (CRT). Initial and 1-year followup data were analyzed both as mean reaction times and as parameters of a fitted two-component quantitative model (the ex-Gaussian model). Slowing of CRT proved to be a sensitive test for AD. Slowing was due to changes in both the sensory/motor and the decisional components of the CRT model. However, these changes were found in both AD and slower, older controls. The modeling of CRT in AD is discussed. © 1990.

引用

页码：148 / 166

页数：19

共 42 条

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