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The role of gene dosage and genetic transpositions in carcinogenesis

被引：711
作者：
Klein, George [1 ]
机构：
[1] Karolinska Inst, Dept Tumor Biol, S-10401 Stockholm, Sweden
来源：
NATURE | 1981年 / 294卷 / 5839期
关键词：
D O I：
10.1038/294313a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Analysis of chromosome translocations associated with B-cell derived tumours and studies of chromosome-15 trisomy in murine leukaemia support the theory, emerging from recent work on tumour viruses, that cancer can be associated with DNA rearrangements which result in the increased expression of normal cellular genes.
引用
收藏
页码：313 / 318
页数：6
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