STRUCTURE OF A GLA-CONTAINING DIPEPTIDE - CRYSTAL-STRUCTURE OF (+-)-N-CARBOBENZOXY-(GAMMA,GAMMA'-DI-TERT-BUTYL)-GAMMA-CARBOXYGLUTAMYLGLYCINE ETHYL-ESTER

被引:10
作者
VALENTE, EJ [1 ]
HISKEY, RG [1 ]
HODGSON, DJ [1 ]
机构
[1] UNIV N CAROLINA,DEPT CHEM,CHAPEL HILL,NC 27514
关键词
Carboxyglutamyl residue; Crystal structure;
D O I
10.1016/0005-2795(79)90074-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The crystal and molecular structure of a dipeptide containing a blocked γ-carboxyglutamyl (Gla) residue is presented. Two intermolecular hydrogen bonds link the amides with carbonyl groups in the dipeptide backbone, but the protected γ-carboxy groups on the modified glutamic acid are not hydrogen bonded. © 1979.
引用
收藏
页码:466 / 468
页数:3
相关论文
共 10 条
[1]  
ANFINSEN CB, 1975, ADV PROTEIN CHEM
[2]   SYNTHESIS OF DL-GAMMA-CARBOXYGLUTAMIC ACID-DERIVATIVES [J].
BOGGS, NT ;
GAWLEY, RE ;
KOEHLER, KA ;
HISKEY, RG .
JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (19) :2850-2851
[3]  
HISKEY RG, 1977, 5TH P AM PEPT S, P465
[4]   PROPERTIES OF A CA2+ BINDING PEPTIDE FROM PROTHROMBIN [J].
HOWARD, JB ;
NELSESTU.GL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 59 (02) :757-763
[5]   PRIMARY STRUCTURE OF VITAMIN-K-DEPENDENT PART OF PROTHROMBIN [J].
MAGNUSSO.S ;
SOTTRUPJ.L ;
PETERSEN, TE ;
MORRIS, HR ;
DELL, A .
FEBS LETTERS, 1974, 44 (02) :189-193
[6]  
MAIN P, 1971, MULTAN COMPUTER PROG
[7]  
SATYSHUR K, 1976, SUM AM CRYST ASS M
[8]  
SATYSHUR K, 1977, SUM AM CRYST ASS M
[9]   VITAMIN-K DEPENDENT MODIFICATIONS OF GLUTAMIC-ACID RESIDUES IN PROTHROMBIN [J].
STENFLO, J ;
FERNLUND, P ;
EGAN, W ;
ROEPSTOR.P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (07) :2730-2733
[10]  
1970, J MOL BIOL, V52, P1