HELPER T-CELL SUBSETS IN MOUSE LEISHMANIASIS - INDUCTION, EXPANSION AND EFFECTOR FUNCTION

被引：180

作者：

LOCKSLEY, RM ^{[1
]}

SCOTT, P ^{[1
]}

机构：

[1] UNIV PENN,SCH VET MED,DEPT PATHOBIOL,PHILADELPHIA,PA 19104

来源：

IMMUNOPARASITOLOGY TODAY-A COMBINED ISSUE OF IMMUNOLOGY TODAY AND PARASITOLOGY TODAY | 1991年 / 03期

关键词：

D O I：

10.1016/S0167-5699(05)80017-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been a surprise to find that the two distinct subsets of mouse CD4+ T cells identified from clones cultured in vitro also occur during Leishmania infection. The spectrum of disease encountered during these infections ranges from successful resolution to fatal dissemination and in mice these outcomes are accompanied by expansion of TH1 or TH2 CD4+ cells, respectively. This review focuses on the mechanisms that cause such disparate responses to the parasite. © 1991 Elsevier Science Publishers Ltd, UK.

引用

页码：A58 / A61

页数：4

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