THE DETECTION OF CHEMICALLY-INDUCED CHROMOSOMAL MALSEGREGATION IN SACCHAROMYCES-CEREVISIAE D61.M - A LITERATURE SURVEY (1984-1990)

被引：17

作者：

ALBERTINI, S ^{[1
]}

ZIMMERMANN, FK ^{[1
]}

机构：

[1] TH DARMSTADT, INST MIKROBIOL, W-6100 DARMSTADT, GERMANY

来源：

MUTATION RESEARCH | 1991年 / 258卷 / 03期

关键词：

CHROMOSOME MALSEGREGATION; SACCHAROMYCES-CEREVISIAE D61.M;

D O I：

10.1016/0165-1110(91)90011-J

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Our objective is to summarize the published data obtained with a recently developed tester strain suitable for the detection of chromosomal malsegregation in yeast. Results from 25 papers were reviewed in which numerical data for 111 chemicals tested in Saccharomyces cerevisiae D61.M are reported (a total of 316 independent tests; 279 acceptable, 37 not meeting our criteria). Of the 111 compounds analyzed 43 compounds are positive for chromosomal malsegregation, 56 compounds are negative and 12 compounds do not meet our criteria for acceptance (inconclusive). Of the 43 compounds judged positive 5 (acetone, acetonitrile, benzonitrile, ethylacetate and propionitrile) were only positive using a cold interruption protocol. Recommendations are made for standardization of methods and protocols for screening purposes. Finally, a comparison with in vitro tubulin assembly data using mammalian tubulin is presented.

引用

页码：237 / 258

页数：22

共 52 条

[1] MOUSE MICRONUCLEUS TESTS WITH KNOWN AND SUSPECT SPINDLE POISONS - RESULTS FROM 2 LABORATORIES [J].

ADLER, ID ;

KLIESCH, U ;

VANHUMMELEN, P ;

KIRSCHVOLDERS, M .

MUTAGENESIS, 1991, 6 (01) :47-53

[2] PHENOBARBITAL INDUCES ANEUPLOIDY IN SACCHAROMYCES-CEREVISIAE AND STIMULATES THE ASSEMBLY OF PORCINE BRAIN TUBULIN [J].

ALBERTINI, S ;

FRIEDERICH, U ;

GROSCHELSTEWART, U ;

ZIMMERMANN, FK ;

WURGLER, FE .

MUTATION RESEARCH, 1985, 144 (02) :67-71

[3] REVERSIBLE INHIBITION OF MAMMALIAN TUBULIN ASSEMBLY INVITRO AND EFFECTS IN SACCHAROMYCES-CEREVISIAE D61.M BY MITOMYCIN-C [J].

ALBERTINI, S ;

FRIEDERICH, U ;

WURGLER, FE .

MUTAGENESIS, 1989, 4 (01) :39-44

[4] INDUCTION OF MITOTIC CHROMOSOME LOSS IN THE DIPLOID YEAST SACCHAROMYCES-CEREVISIAE D61.M BY GENOTOXIC CARCINOGENS AND TUMOR PROMOTERS [J].

ALBERTINI, S ;

FRIEDERICH, U ;

WURGLER, FE .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1988, 11 (04) :497-508

[5] INFLUENCE OF DIFFERENT FACTORS ON THE INDUCTION OF CHROMOSOME MALSEGREGATION IN SACCHAROMYCES-CEREVISIAE D61.M BY BAVISTAN AND ASSESSMENT OF ITS GENOTOXIC PROPERTY IN THE AMES TEST AND IN SACCHAROMYCES-CEREVISIAE D7 [J].

ALBERTINI, S .

MUTATION RESEARCH, 1989, 216 (06) :327-340

[6] REEVALUATION OF THE 9 COMPOUNDS REPORTED CONCLUSIVE POSITIVE IN YEAST SACCHAROMYCES-CEREVISIAE ANEUPLOIDY TEST SYSTEMS BY THE GENE-TOX PROGRAM USING STRAIN D61.M OF SACCHAROMYCES-CEREVISIAE [J].

ALBERTINI, S .

MUTATION RESEARCH, 1991, 260 (02) :165-180

[7] ANALYSIS OF 9 KNOWN OR SUSPECTED SPINDLE POISONS FOR MITOTIC CHROMOSOME MALSEGREGATION USING SACCHAROMYCES-CEREVISIAE D61.M [J].

ALBERTINI, S .

MUTAGENESIS, 1990, 5 (05) :453-459

[8] THE INVITRO PORCINE BRAIN TUBULIN ASSEMBLY ASSAY - EFFECTS OF A GENOTOXIC CARCINOGEN (AFLATOXIN-B1), 8 TUMOR PROMOTERS AND 9 MISCELLANEOUS SUBSTANCES [J].

ALBERTINI, S ;

FRIEDERICH, U ;

HOLDEREGGER, C ;

WURGLER, FE .

MUTATION RESEARCH, 1988, 201 (02) :283-292

[9] 2,5-HEXANEDIONE ALTERS MICROTUBULE ASSEMBLY .2. ENHANCED POLYMERIZATION OF CROSS-LINKED TUBULIN [J].

BOEKELHEIDE, K .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 88 (03) :383-396

[10] EFFECTS OF 10 KNOWN OR SUSPECTED SPINDLE POISONS IN THE INVITRO PORCINE BRAIN TUBULIN ASSEMBLY ASSAY [J].

BRUNNER, M ;

ALBERTINI, S ;

WURGLER, FE .

MUTAGENESIS, 1991, 6 (01) :65-70

← 1 2 3 4 5 6 →