H-1-NMR STUDY OF THE SOLUTION STRUCTURE OF SARAFOTOXIN-S6B

被引：26

作者：

AUMELAS, A ^{[1
]}

CHICHE, L ^{[1
]}

MAHE, E ^{[1
]}

LENGUYEN, D ^{[1
]}

SIZUN, P ^{[1
]}

BERTHAULT, P ^{[1
]}

PERLY, B ^{[1
]}

机构：

[1] CENS,SERV CHIM MOLEC,F-91190 GIF SUR YVETTE,FRANCE

来源：

NEUROCHEMISTRY INTERNATIONAL | 1991年 / 18卷 / 04期

关键词：

D O I：

10.1016/0197-0186(91)90141-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sarafotoxin-S6b has been synthesized and studied by H-1 NMR in 50/50 acetonitrile/water mixture. All spin systems were identified and assigned with the aid of 2D experiments. On the basis of these data, a 3D structure of sarafotoxin is proposed and compared to that of [Nle7]endothelin obtained in the same conditions. From this study, it appeared that sarafotoxin-S6b and [Nle7]endothelin roughly share the same 3D structure, the main differences being located in the 4-7 loop bearing the sequence variation.

引用

页码：471 / 475

页数：5

共 12 条

[1]

AUMELAS A, 1991, IN PRESS INT J PEPTI

[2] SRTX-D, A NEW NATIVE PEPTIDE OF THE ENDOTHELIN SARAFOTOXIN FAMILY [J].