TRABECULAR BONE REMODELING - AN EXPERIMENTAL-MODEL

被引:138
作者
GOLDSTEIN, SA
MATTHEWS, LS
KUHN, JL
HOLLISTER, SJ
机构
[1] The Orthopaedic Research Laboratories, The University of Michigan, Section of Orthopaedic Surgery, Ann Arbor
关键词
D O I
10.1016/0021-9290(91)90384-Y
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
An experimental model, capable of inducing controlled stress fields to the distal femoral metaphyses of large dogs, is presented. This model utilized an implantable hydraulic device incorporating five loading cylinders and platens in direct contact with an exposed plane of trabecular bone. A microprocessor controls the loading characteristics, and finite element models were created to calculate the induced stress and strain fields. The trabecular remodeling response is measured using serial in vivo computed tomography, in vitro microcomputed tomography, and histologic analysis. The results of the experiment indicate that significant remodeling can be induced by the activated implant. An increase in trabecular orientation toward the loaded platens was observed, and a statistically significant decrease in connectivity was documented. The greatest effect was associated with a change in the loading rate. A fast rise time (70 ms) loading waveform induced significant bone ingrowth at the implant interface when compared to a slow rise time waveform (700 ms), and demonstrated high correlations with the calculated stress fields as remodeling approached an equilibrium state.
引用
收藏
页码:135 / +
页数:1
相关论文
共 58 条
[1]  
BEAUPRE GS, 1989, T ORTHOP RES SOC, V14, P311
[2]   THE TRANSDUCTION OF MECHANICAL FORCE INTO BIOCHEMICAL EVENTS IN BONE-CELLS MAY INVOLVE ACTIVATION OF PHOSPHOLIPASE-A2 [J].
BINDERMAN, I ;
ZOR, U ;
KAYE, AM ;
SHIMSHONI, Z ;
HARELL, A ;
SOMJEN, D .
CALCIFIED TISSUE INTERNATIONAL, 1988, 42 (04) :261-266
[3]  
BRUNSKI JB, 1988, NONCEMENTAL TOTAL HI
[4]   BONE REMODELING IN RESPONSE TO INVIVO FATIGUE MICRODAMAGE [J].
BURR, DB ;
MARTIN, RB ;
SCHAFFLER, MB ;
RADIN, EL .
JOURNAL OF BIOMECHANICS, 1985, 18 (03) :189-&
[5]  
CARTER DR, 1982, CRIT REV BIOMED ENG, V8, P1
[6]   TRABECULAR BONE-DENSITY AND LOADING HISTORY - REGULATION OF CONNECTIVE-TISSUE BIOLOGY BY MECHANICAL ENERGY [J].
CARTER, DR ;
FYHRIE, DP ;
WHALEN, RT .
JOURNAL OF BIOMECHANICS, 1987, 20 (08) :785-+
[7]   MECHANICAL LOADING HISTORIES AND CORTICAL BONE REMODELING [J].
CARTER, DR .
CALCIFIED TISSUE INTERNATIONAL, 1984, 36 :S19-S24
[8]  
CARTER DR, 1988, NONCEMENTED TOTAL HI
[9]   MECHANICAL INFLUENCES IN BONE REMODELING - EXPERIMENTAL RESEARCH ON WOLFFS LAW [J].
CHAMAY, A ;
TSCHANTZ, P .
JOURNAL OF BIOMECHANICS, 1972, 5 (02) :173-&
[10]   TRABECULAR BONE REMODELING AROUND SMOOTH AND POROUS IMPLANTS IN AN EQUINE PATELLAR MODEL [J].
CHEAL, EJ ;
SNYDER, BD ;
NUNAMAKER, DM ;
HAYES, WC .
JOURNAL OF BIOMECHANICS, 1987, 20 (11-12) :1121-1134