EFFECT OF PLATELET-ACTIVATING-FACTOR ON CORTISOL AND CORTICOSTERONE SECRETION BY PERFUSED DOG ADRENAL

被引：9

作者：

AIKAWA, T ^{[1
]}

HIROSE, T ^{[1
]}

MATSUMOTO, I ^{[1
]}

MORIKAWA, T ^{[1
]}

SHIMADA, T ^{[1
]}

MINE, Y ^{[1
]}

TSUJIMOTO, Y ^{[1
]}

TSUJI, Y ^{[1
]}

机构：

[1] NAGASAKI UNIV,SCH MED,DEPT PEDIAT,NAGASAKI 852,JAPAN

来源：

LIPIDS | 1991年 / 26卷 / 12期

关键词：

D O I：

10.1007/BF02536511

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Administration of platelet-activating factor (PAF) to perfused adrenal increased cortisol and corticosterone secretion. With hexadecyl PAF (C16PAF; 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine), the increase was significant at 1 nM and maximal at 10 nM. The responses to 10 nM octadecyl PAF (C18PAF; 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) were one fourth of those to 10 nM C16PAF. The addition Of C16PAF to dispersed adrenal cells significantly increased cortisol and corticosterone production at 0.1 nM and 10 nM, respectively. C16PAF was about 1000 times more potent than histamine on a molar basis in respect to cortisol response in both perfused adrenal and dispersed adrenal cells. The results suggest that PAF induces cortisol release from dog adrenal.

引用

页码：1108 / 1111

页数：4

共 16 条

[1]

AIKAWA T, 1981, JPN J PHYSIOL, V31, P457

[2] H-1 ACTION OF HISTAMINE ON ALDOSTERONE AND CORTISOL SECRETION BY PERFUSED DOG ADRENAL [J].