CLONING AND MODULATION BY ENDOTHELIN-1 OF RAT CARDIAC K-CHANNEL

被引：20

作者：

ISHII, K

NUNOKI, K

MURAKOSHI, H

TAIRA, N

机构：

[1] Department of Pharmacology, Tohoku University School of Medicine, Sendai

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)80050-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned a delayed rectifier type K channel from rat heart (RH1). RH1 was identical to the rat brain K channel BK2 and differed from recently cloned rat cardiac K channel RAK by one amino acid residue. Endothelin receptors(ETRs)-mediated modulation of RH1 current (IRH1) was studied using Xenopus oocyte expression system. Activation of two different subtypes of ETRs by endothelin-1 equally suppressed the amplitude of IRH1. Stimulation of phosphatidylinositol turnover will probably be responsible for the suppression. © 1992 Academic Press, Inc.

引用

页码：1484 / 1489

页数：6

共 32 条

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