SULFATIDE AS A BIOCHEMICAL MARKER IN CEREBROSPINAL-FLUID OF PATIENTS WITH VASCULAR DEMENTIA

被引:54
作者
FREDMAN, P [1 ]
WALLIN, A [1 ]
BLENNOW, K [1 ]
DAVIDSSON, P [1 ]
GOTTFRIES, CG [1 ]
SVENNERHOLM, L [1 ]
机构
[1] ST JORGENS HOSP, DEPT PSYCHIAT & NEUROCHEM, S-42203 HISINGS BACKA, SWEDEN
来源
ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 85卷 / 02期
关键词
BIOLOGICAL MARKERS IN CSF; SULFATIDE; DEMYELINATION; DEMENTIA; ALZHEIMERS DISEASE; VASCULAR DEMENTIA;
D O I
10.1111/j.1600-0404.1992.tb04006.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The myelin-associated glycosphingolipid sulfatide in cerebrospinal fluid (CSF) was investigated in 20 patients with vascular dementia (VAD), 43 with Alzheimer's disease (AD) and 20 age-matched controls. The sulfatide concentration in the VAD group (307 +/- 118 nmol/l) was significantly (p < 0.0001) higher than that in controls (145 +/- 86 nmol/l) and the AD group (178 +/- 79 nmol/l). Among the VAD patients, 8/20 had a significantly increased concentration of sulfatide (> mean + 2 S.D.), as compared with controls, while only 2/43 of the AD patients had a sulfatide concentration above this level. It is suggested that the elevated concentration of sulfatide in CSF from VAD patients reflects demyelination. Furthermore, sulfatide determinations, when combined with clinical findings, may be of diagnostic value, for discriminating between VAD and AD.
引用
收藏
页码:103 / 106
页数:4
相关论文
共 15 条
[1]  
BLENNOW K, IN PRESS ARCH NEUROL
[2]   DETERMINATION OF GANGLIOSIDES AND SULFATIDE IN HUMAN CEREBROSPINAL-FLUID WITH A MICROIMMUNOAFFINITY TECHNIQUE [J].
DAVIDSON, P ;
FREDMAN, P ;
MANSSON, JE ;
SVENNERHOLM, L .
CLINICA CHIMICA ACTA, 1991, 197 (02) :105-115
[3]   CELL-SURFACE SHEDDING - PHENOMENON AND ITS POSSIBLE SIGNIFICANCE [J].
DOLJANSKI, F ;
KAPELLER, M .
JOURNAL OF THEORETICAL BIOLOGY, 1976, 62 (02) :253-270
[4]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[5]   CHARACTERIZATION OF THE BINDING EPITOPE OF A MONOCLONAL-ANTIBODY TO SULFATIDE [J].
FREDMAN, P ;
MATTSSON, L ;
ANDERSSON, K ;
DAVIDSSON, P ;
ISHIZUKA, I ;
JEANSSON, S ;
MANSSON, JE ;
SVENNERHOLM, L .
BIOCHEMICAL JOURNAL, 1988, 251 (01) :17-22
[6]   MOLECULAR-SIZE OF MYELIN BASIC-PROTEIN IMMUNOACTIVITY IN SPINAL-FLUID [J].
KARLSSON, B ;
ALLING, C .
JOURNAL OF NEUROIMMUNOLOGY, 1984, 6 (03) :141-150
[7]   ELECTROIMMUNO ASSAY [J].
LAURELL, CB .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1972, 29 :21-&
[8]  
MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
[9]   LIPID COMPOSITION OF PURIFIED BOVINE BRAIN MYELIN [J].
NORTON, WT ;
AUTILIO, LA .
JOURNAL OF NEUROCHEMISTRY, 1966, 13 (04) :213-&
[10]   CELL-TYPE-SPECIFIC MARKERS FOR DISTINGUISHING AND STUDYING NEURONS AND THE MAJOR CLASSES OF GLIAL-CELLS IN CULTURE [J].
RAFF, MC ;
FIELDS, KL ;
HAKOMORI, SI ;
MIRSKY, R ;
PRUSS, RM ;
WINTER, J .
BRAIN RESEARCH, 1979, 174 (02) :283-308