THE ROLE OF EPIDURAL FIBROSIS AND DEFECTIVE FIBRINOLYSIS IN THE PERSISTENCE OF POSTLAMINECTOMY BACK PAIN

被引：79

作者：

COOPER, RG

MITCHELL, WS

ILLINGWORTH, KJ

FORBES, WS

GILLESPIE, JE

JAYSON, MIV

机构：

[1] Rheumatic Diseases Centre, University of Manchester

[2] Department of Radiology, Hope Hospital, Salford

来源：

SPINE | 1991年 / 16卷 / 09期

关键词：

POSTSURGICAL ARACHNOIDITIS; EPIDURAL FIBROSIS; SPINAL SURGERY; LOW-BACK PAIN; FIBRINOLYSIS;

D O I：

10.1097/00007632-199109000-00005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Clinical features, contrast-enhanced lumbar tomographic findings, and biochemical plasma fibrinolytic parameters were critically assessed in 70 patients suffering severe, chronic postsurgical low-back and radicular pain to determine the cause of their persisting symptoms. Patients exhibited gross functional disability and significant impairment of plasma fibrinolytic activity, compared with 84 normal control subjects. This fibrinolytic defect appeared attributable to disproportionate increases in circulating plasminogen activator inhibitor-1 levels. Clinical features were slightly worse in patients with radiologic epidural fibrosis, whereas the frequency of radiologic abnormalities, including epidural fibrosis, was higher in patients with fibrinolytic abnormalities. The results, however, demonstrated no significant associations between patients' symptoms and signs and their biochemical and radiologic abnormalities.

引用

页码：1044 / 1048

页数：5

共 44 条

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