IDENTIFICATION OF A WHOLE-ARM TRANSLOCATION BY INSITU HYBRIDIZATION WITH DIRECTLY FLUOROCHROME-LABELED PROBES IN A MYELODYSPLASTIC SYNDROME

被引：7

作者：

BAJALICA, S

BRONDUMNIELSEN, K

SORENSEN, AG

PEDERSEN, NT

HEIM, S

机构：

[1] LUND UNIV HOSP,DEPT CLIN GENET,LUND,SWEDEN

[2] KAROLINSKA HOSP,DEPT CLIN GENET,S-10401 STOCKHOLM 60,SWEDEN

[3] ODENSE UNIV,DEPT MED GENET,DK-5230 ODENSE,DENMARK

[4] ODENSE HOSP,DEPT PATHOL,ODENSE,DENMARK

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 5卷 / 02期

关键词：

D O I：

10.1002/gcc.2870050206

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case of myelodysplasia was found to have a complex bone marrow karyotype, involving an apparent whole-arm translocation between 17q and 18q. The application of a simplified fluorescence in situ hybridization technique, using directly fluorochrome-labeled centromere-specific alpha-satellite DNA probes, demonstrated the presence of sequences from both chromosomes 17 and 18 in the centromere of the derivative chromosome. This proves that a true whole-arm translocation had occurred. The case exemplifies how in situ hybridization analysis can be used to resolve interpretation problems in cancer cytogenetics.

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页码：128 / 131

页数：4

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