ANTIFUNGAL ACTIVITY OF MERIDINE, A NATURAL PRODUCT FROM THE MARINE SPONGE CORTICIUM SP

被引：91

作者：

MCCARTHY, PJ

PITTS, TP

GUNAWARDANA, GP

KELLYBORGES, M

POMPONI, SA

机构：

[1] Division of Biomedical Marine Research, Harbor Branch Oceanographic Insitutiton, Fort Pierce, Florida 34946

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 11期

关键词：

D O I：

10.1021/np50089a016

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Meridine [1], a polycyclic alkaloid derived from the marine sponge Corticium sp., was found to inhibit the growth of Candida albicans and Cryptococcus neoformans. Activity was also observed against Trichophyton mentagrophytes and Epidermophyton floccosum. Studies of the mechanism of action of this agent have shown an inhibition of nucleic acid biosynthesis.

引用

页码：1664 / 1668

页数：5

共 12 条

[1]

H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].

BAX, A ;

SUMMERS, MF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094

[2]

TOPOISOMERASE-II - A POTENTIAL TARGET FOR NOVEL ANTIFUNGAL AGENTS [J].

FIGGITT, DP ;

DENYER, SP ;

DEWICK, PM ;

JACKSON, DE ;

WILLIAMS, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (01) :257-262

[3]

A NOVEL ANTIFUNGAL FROM AN ACTINOMADURAE WITH PREFERENTIAL ACTIVITY AGAINST THE MYCELIAL PHASE OF CANDIDA-ALBICANS [J].

GULLO, V ;

GUNNARSSON, I ;

HEGDE, V ;

HORAN, A ;

LOEBENBERG, D ;

MARQUEZ, J ;

PATEL, M ;

PUAR, M ;

SCHWARTZ, J .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1991, 8 (01) :65-68

[4]

DERCITIN, A NEW BIOLOGICALLY-ACTIVE ACRIDINE ALKALOID FROM A DEEP-WATER MARINE SPONGE, DERCITUS SP [J].

GUNAWARDANA, GP ;

KOHMOTO, S ;

GUNASEKERA, SP ;

MCCONNELL, OJ ;

KOEHN, FE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (14) :4856-4858

[5]

HAMAMOTO T, 1986, J ANTIBIOT, V38, P1573

[6]

HECHTEL GJ, 1965, YALE U PEABODY MUSEU, V20, P77

[7]

HUANG TK, 1964, J ANTIBIOT A, V17, P65

[8]

Lurian V, 1986, ANTIBIOTICS LAB MED, P93

[9]

MODE OF ACTION OF 5-FLUOROCYTOSINE AND MECHANISMS OF RESISTANCE [J].

POLAK, A ;

SCHOLER, HJ .

CHEMOTHERAPY, 1975, 21 (3-4) :113-130

[10]

Ryley J. F., 1984, Mode of action of antifungal agents, P63

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