CYLINDRICINE-A AND CYLINDRICINE-B, NOVEL ALKALOIDS FROM THE ASCIDIAN CLAVELINA-CYLINDRICA

被引：132

作者：

BLACKMAN, AJ ^{[1
]}

LI, CP ^{[1
]}

HOCKLESS, DCR ^{[1
]}

SKELTON, BW ^{[1
]}

WHITE, AH ^{[1
]}

机构：

[1] UNIV WESTERN AUSTRALIA,DEPT CHEM,NEDLANDS,WA 6009,AUSTRALIA

来源：

TETRAHEDRON | 1993年 / 49卷 / 38期

关键词：

D O I：

10.1016/S0040-4020(01)96270-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ascidian Clavelina cylindrica, which was collected in Tasmania, has yielded two novel alkaloids, cylindricine A, rel-(3R,4R,5S,7aR,11aR)-3-chloromethyl-5-hexyl-perhydro-pyrrolo-[2,1-j]quinolin-7-one, (12), and cylindricine B. rel-(3S,5R,6S,8aR,12aR)-3-chloro-6-hexyl-perhydropyrido[2,1-j]quinoline-8-one, (13). Cylindricine B is the first example of the new pyrido-[2,1-j]-quinoline ring system while cylindricine A is the first pyrrolo[2,1-j]quinoline known from nature. Single crystal X-ray studies support the assignment of the two alkaloids.

引用

页码：8645 / 8656

页数：12

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