TRANSIENT IMPROVEMENT OF CONGENITAL LACTIC-ACIDOSIS IN A MALE INFANT WITH PYRUVATE DECARBOXYLASE DEFICIENCY TREATED WITH DICHLOROACETATE

被引：19

作者：

TOTH, PP

ELSHANTI, H

EIVINS, S

RHEAD, WJ

KLEIN, JM

机构：

[1] UNIV IOWA, DEPT PEDIAT, IOWA CITY, IA 52242 USA

[2] UNIV IOWA, DEPT OBSTET GYNECOL, IOWA CITY, IA 52242 USA

来源：

JOURNAL OF PEDIATRICS | 1993年 / 123卷 / 03期

关键词：

D O I：

10.1016/S0022-3476(05)81751-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A comatose male newborn infant with congenital lactic acidosis caused by pyruvate decarboxylase deficiency was treated with dichloroacetate (DCA), which stimulated an 88% drop in serum lactate concentration and reversed his coma. The response to DCA was temporary and the lactic acidosis worsened until his death, but DCA may confer more lasting benefit in less severely affected infants.

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页码：427 / 430

页数：4

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