PICROTOXIN CHANGES THE EFFECTS OF IMIPRAMINE AND DESIPRAMINE IN RATS IN THE FORCED SWIMMING TEST

被引：10

作者：

FERNANDEZTERUEL, A

ESCORIHUELA, RM

BOIX, F

TOBENA, A

机构：

[1] Medical Psychology Unit, Department of Pharmacology and Psychiatry, School of Medicine, 08193 Bellaterra, Barcelona

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 181卷 / 1-2期

关键词：

Desipramine; Forced swimming test; GABA[!sub]A[!/sub]-benzodiazepine-Cl complex; Imipramine; Open field; Picrotoxin;

D O I：

10.1016/0014-2999(90)90242-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim was to find whether the chloride channel blocker, picrotoxin, at subconvulsant doses could affect the activity of imipramine or desipramine in the 'forced swimming' test with rats. It was found that picrotoxin enhanced the anti-immobility effects of imipramine and desipramine whereas open field activity remained unaffected or was even decreased by the same treatments. The results seem consistent with recent reports showing direct interactions between several antidepressant drugs and the GABAA receptor/benzodiazepine receptor/chloride ionophore complex (GABAA/benzodiazepine/Cl complex). The results also conform with the hypothesis that a reduction in the functionality of this complex could be related to the clinical effects of antidepressant drugs. © 1990.

引用

页码：35 / 41

页数：7

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