IMMUNITY IN WART RESOLUTION

被引：9

作者：

ADLER, A ^{[1
]}

SAFAI, B ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1979年 / 1卷 / 04期

关键词：

D O I：

10.1016/S0190-9622(79)70023-5

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The involvement of the humoral and cell-mediated immune systems in the regression of wart infection has been investigated extensively in recent years. This review examines the supporting evidence for the roles of humoral and cellular immunity in wart regression and its possible implications. From the available data it does not appear that a conclusion can be drawn that only humoral or cell-mediated immunity is involved, or that both are essential, in the regression of wart infection. Studies by several investigators, however, suggest that, since agents known to stimulate the cell-mediated immune system have been reported to be followed by the successful resolution of warts, the cell-mediated immune system appears to play a critical role in wart resolution. It may be that the direction which should be taken in eradication of warts resistant to conventional modalities of treatment is one which relies upon the stimulation of the patient's immune system in a very specific manner. Probably the most efficient way to accomplish this, based on available data, would be by autogenous vaccination. Following the patient's humoral and cell-mediated immune response prior to, during, and following treatment with autogenous vaccination may help to elucidate the precise mechanism by which the successful resolution of warts occurs. © 1979, American Academy of Dermatology, Inc.. All rights reserved.

引用

页码：305 / 309

页数：5

共 41 条

[1]

Rowsen KEK, Mahy BWJ, Human papova (wart) virus, Bacteriol Rev, 31, pp. 110-131, (1967)

[2]

Delap RJ, Yanagi K, Rush MG, Analysis of the structure papilloma virus DNA, Arch Virol, 54, pp. 263-269, (1977)

[3]

Goldschmidt H, Kligman AM, Experimental inoculation of humans with ectodermotrophic viruses, J Invest Dermatol, 31, pp. 175-182, (1958)

[4]

Pass F, Reissig M, Shah KV, Et al., Identification of an immunologically distinct papilloma virus from lesions of epidermodysplasia verruciformis, J Natl Cancer Inst, 59, pp. 1107-1112, (1977)

[5]

Gissman L, Pfister H, zur Hausen H, Human papilloma virus. Characterization of four different isolates, Virology, 76, pp. 569-580, (1977)

[6]

Gissman L, zur Hausen H, Human papilloma virus DNA, Physical mapping and genetic heterogeneity, Proceedings of the National Academy of Sciences, 73, pp. 1310-1313, (1976)

[7]

Massing AM, Epstein WL, Natural history of warts: A two year study, Arch Dermatol, 7, pp. 306-310, (1963)

[8]

Spencer EJ, Anderson HK, Clinically evident nonterminal infection with herpes virus and wart virus in immu-nosuppressed renal allograft recipients, Br Med J, 3, pp. 251-254, (1970)

[9]

Perry TL, Harman L, Warts in diseases with immune defects, Cutis, 13, pp. 359-362, (1974)

[10]

Matthews RS, Shirodaria PV, Study of regressing warts by immunofluorescence, Lancet, 1, pp. 689-691, (1973)

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