PLASMODIUM-FALCIPARUM SEXUAL STAGE ANTIGENS - IMMUNOGENICITY AND CELL-MEDIATED RESPONSES

被引：36

作者：

TARGETT, GAT ^{[1
]}

HARTE, PG ^{[1
]}

EIDA, S ^{[1
]}

ROGERS, NC ^{[1
]}

ONG, CSL ^{[1
]}

机构：

[1] PAISLEY COLL TECHNOL,DEPT BIOL,PAISLEY PA1 2BE,RENFREW,SCOTLAND

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 1-3期

基金：

英国惠康基金;

关键词：

B cell epitope; Gamete antigen; Immune regulation; Interferon-γ; Lymphoproliferation; Malaria;

D O I：

10.1016/0165-2478(90)90095-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibody and cell-mediated immune responses to the transmission-blocking target antigens of Plasmodium falciparum, Pfs 48/45, were determined in infected non-immune patients and in immune individuals from an endemic area. Characterization of the B cell epitopes with monoclonal antibodies showed that there were five regions identifiable but there could be interactions between them causing either competitive or enhancing effects. Sera from infected non-immune patients contained antibodies that would compete with one or more of the mAbs to the different epitopes. Immune responsiveness to purified Pfs 48/45 in P. falciparum-immune adults measured as lymphoproliferation, production of interferon-γ, or as Pfs 48/45-specific antibody was very limited. This did not appear to be due to MHC class II restriction, to diversity in structure of the parasite antigens or to a failure of immunological memory. The antibody-response data were more consistent with down-regulation of immunity as a result of prolonged exposure to infection. © 1990.

引用

页码：77 / 82

页数：6

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