Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells

被引：178

作者：

Graf, Thomas ^{[1
]}

机构：

[1] European Mol Biol Lab, Differentiat Programme, Meyerhofstr 1, D-6900 Heidelberg, Germany

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1992年 / 2卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(05)80281-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Myb is a transcriptional activator protein with repeated helix-turn-helix DNA-binding motifs distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-Myb is activated are complex and involve truncations, point mutations, and fusion or coexpression with other proteins.

引用

页码：249 / 255

页数：7

共 42 条

[1] ALTIERI M, 1991, BLOOD, V77, P1181
[2] ESTROGEN-DEPENDENT ALTERATIONS IN DIFFERENTIATION STATE OF MYELOID CELLS CAUSED BY A V-MYB ESTROGEN-RECEPTOR FUSION PROTEIN
BURK, O
KLEMPNAUER, KH
[J]. EMBO JOURNAL, 1991, 10 (12) : 3713 - 3719
[3] NORMAL AND LEUKEMIC HEMATOPOIETIC-CELLS MANIFEST DIFFERENTIAL SENSITIVITY TO INHIBITORY EFFECTS OF C-MYB ANTISENSE OLIGODEOXYNUCLEOTIDES - AN INVITRO STUDY RELEVANT TO BONE-MARROW PURGING
CALABRETTA, B
SIMS, RB
VALTIERI, M
CARACCIOLO, D
SZCZYLIK, C
VENTURELLI, D
RATAJCZAK, M
BERAN, M
GEWIRTZ, AM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) : 2351 - 2355
[4] STAGE-RELATED PROLIFERATIVE ACTIVITY DETERMINES C-MYB FUNCTIONAL REQUIREMENTS DURING NORMAL HUMAN HEMATOPOIESIS
CARACCIOLO, D
VENTURELLI, D
VALTIERI, M
PESCHLE, C
GEWIRTZ, AM
CALABRETTA, B
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (01) : 55 - 61
[5] The myb and myc nuclear oncogenes as transcriptional activators
Cole, M. D.
[J]. CURRENT OPINION IN CELL BIOLOGY, 1990, 2 (03) : 502 - 508
[6] PROPOSED STRUCTURE FOR THE DNA-BINDING DOMAIN OF THE MYB ONCOPROTEIN BASED ON MODEL-BUILDING AND MUTATIONAL ANALYSIS
FRAMPTON, J
GIBSON, TJ
NESS, SA
DODERLEIN, G
GRAF, T
[J]. PROTEIN ENGINEERING, 1991, 4 (08): : 891 - 901
[7] DNA-BINDING DOMAIN ANCESTRY
FRAMPTON, J
LEUTZ, A
GIBSON, TJ
GRAF, T
[J]. NATURE, 1989, 342 (6246) : 134 - 134
[8] SPECIFIC DNA-BINDING BY C-MYB - EVIDENCE FOR A DOUBLE HELIX-TURN-HELIX-RELATED MOTIF
GABRIELSEN, OS
SENTENAC, A
FROMAGEOT, P
[J]. SCIENCE, 1991, 253 (5024) : 1140 - 1143
[9] A C-MYB ANTISENSE OLIGODEOXYNUCLEOTIDE INHIBITS NORMAL HUMAN HEMATOPOIESIS INVITRO
GEWIRTZ, AM
CALABRETTA, B
[J]. SCIENCE, 1988, 242 (4883) : 1303 - 1306
[10] A SINGLE POINT MUTATION IN THE V-ETS ONCOGENE AFFECTS BOTH ERYTHROID AND MYELOMONOCYTIC CELL-DIFFERENTIATION
GOLAY, J
INTRONA, M
GRAF, T
[J]. CELL, 1988, 55 (06) : 1147 - 1158

← 1 2 3 4 5 →