A NEW INHIBITOR OF PROTEIN-KINASE-C, RK-1409 (7-OXOSTAUROSPORINE) .2. FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE

被引：32

作者：

KOSHINO, H ^{[1
]}

OSADA, H ^{[1
]}

ISONO, K ^{[1
]}

机构：

[1] RIKEN,INST PHYS & CHEM RES,ANTIBIOT LAB,WAKO,SAITAMA 35101,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 02期

关键词：

D O I：

10.7164/antibiotics.45.195

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

RK-1409, a new inhibitor of protein kinase C, was isolated from the culture broth of Streptomyces platensis subsp. malvinus RK-1409. The structure was elucidated as 7-oxostaurosporine on the basis of spectroscopic analyses and oxidation of staurosporine.

引用

页码：195 / 198

页数：4

共 16 条

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