SYNTHESIS AND ANTIHISTAMINIC ACTIVITY OF SOME THIAZOLIDIN-4-ONES

被引：147

作者：

DIURNO, MV ^{[1
]}

MAZZONI, O ^{[1
]}

PISCOPO, E ^{[1
]}

CALIGNANO, A ^{[1
]}

GIORDANO, F ^{[1
]}

BOLOGNESE, A ^{[1
]}

机构：

[1] FAC SCI NAPOLI,I-80134 NAPLES,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 15期

关键词：

D O I：

10.1021/jm00093a025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 2-(4- and 3-substituted phenyl)-3-[3-(N,N-dimethylamino)propyl]-1,3-thiazolidin-4-ones were synthesized, characterized, and evaluated for their ability to inhibit the contractions induced by histamine on guinea pig ileum. The measurement of pA2 values suggested that the reported compounds showed H-1-antagonism. The more active compounds 5, 9, and 13 exhibited activity close to that of mepyramine.

引用

页码：2910 / 2912

页数：3

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