ADVERSE INTERACTION BETWEEN WARFARIN AND INDOMETHACIN

被引：10

作者：

CHAN, TYK

LUI, SF

CHUNG, SY

LUK, S

CRITCHLEY, JAJH

机构：

[1] Department of Clinical Pharmacology and Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories

来源：

DRUG SAFETY | 1994年 / 10卷 / 03期

关键词：

D O I：

10.2165/00002018-199410030-00006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A 57-year-old man developed spontaneous skin bruising and haematuria during combined therapy with warfarin and indomethacin. Due to the potential effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the anticoagulant action of warfarin and platelet function, patients receiving both warfarin and NSAIDs should have their prothrombin time monitored very closely. Also, the risk of gastrointestinal haemorrhage with any NSAIDs must always be remembered.

引用

页码：267 / 269

页数：3

共 10 条

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[8] Self T.H., Evans W.E., Ferguson T., Drug enhancement of warfarin activity, Lancet, 2, (1975)
[9] Vessel E.S., Passananti G.T., Johnson A.O., Failure of indomethacin and warfarin to interact in normal human volunteers, Journal of Clinical Pharmacology, 15, pp. 486-495, (1975)
[10] Yip A.S.B., Chow W.H., Tai Y.T., Cheung K.L., Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unrecognized potential hazard, Postgraduate Medical Journal, 66, pp. 367-369, (1990)

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