1-ALPHA-HYDROXYVITAMIN D-3 INHIBITS TYPE-II COLLAGEN-INDUCED ARTHRITIS IN RATS

被引：40

作者：

TSUJI, M

FUJII, K

NAKANO, T

NISHII, Y

机构：

[1] JIKEI UNIV,SCH MED,DEPT ORTHOPAED SURG,MINATO KU,TOKYO,TOKYO 105,JAPAN

[2] CHUGAI PHARMACEUT CO LTD,RES LABS,TOSHIMA KU,TOKYO,TOKYO 171,JAPAN

来源：

FEBS LETTERS | 1994年 / 337卷 / 03期

关键词：

1-ALPHA-HYDROXYVITAMIN D-3; COLLAGEN-INDUCED ARTHRITIS; ANTI-TYPE II COLLAGEN ANTIBODY; RHEUMATOID ARTHRITIS;

D O I：

10.1016/0014-5793(94)80201-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of 1 alpha-hydroxyvitamin D-3 and 24,25-dihydroxyvitamin D-3 on Type II collagen-induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1 alpha-hydroxyvitamin D-3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti-Type II collagen antibodies was decreased in the 1 alpha-hydroxyvitamin D-3 treated-group. In contrast, 24,25-dihydroxyvitamin D-3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1 alpha-hydroxyvitamin D-3 on Type II collagen-induced arthritis in rats and indicate that it has an antirheumatic effect.

引用

页码：248 / 250

页数：3

共 17 条

[1] INDUCTION OF MONOCYTIC DIFFERENTIATION AND BONE-RESORPTION BY 1,25-DIHYDROXYVITAMIN-D3 [J].