INSULIN RESPONSES FOLLOWING GLUCOSE-ADMINISTRATION IN MENSTRUATING WOMEN

被引:10
作者
EZENWAKA, EC [1 ]
AKANJI, AO [1 ]
ADEJUWON, CA [1 ]
ABBIYESUKU, FM [1 ]
AKINLADE, KS [1 ]
机构
[1] UNIV COLL HOSP IBADAN, COLL MED, DEPT CHEM PATHOL, METAB RES UNIT, IBADAN, NIGERIA
关键词
INSULIN RESISTANCE; GLUCOSE TOLERANCE; MENSTRUAL CYCLE;
D O I
10.1016/0020-7292(93)90630-F
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
OBJECTIVE: The aim of the study was to investigate changes in insulin sensitivity during the menstrual cycle, in a group of regularly menstruating black African women. METHOD: Insulin responses to intravenous glucose (300 mg/kg) were assessed, for up to 3 h, in 3 groups of age- and body mass-matched non-obese sedentary Nigerian women: Group A, 7 women in the menstrual follicular phase; Group B, 7 women in the menstrual luteal phase; C, 7 men. RESULT: Women in the menstrual luteal phase had the greatest integrated first-phase insulin response and insulin/glucose ratios, much higher than the similar values for these variables obtained in other groups. This suggests that the menstrual luteal phase is associated with relative insulin resistance. CONCLUSION: Black African women in the menstrual luteal phase demonstrate an exaggerated insulin response to an acute glucose load and are thus relatively insulin-insensitive. This confirms previous observations in Caucasians.
引用
收藏
页码:155 / 159
页数:5
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