MIANSERIN ION-SELECTIVE MEMBRANE-ELECTRODE AND ITS PHARMACEUTICAL APPLICATIONS

被引：4

作者：

BUNACIU, AA

IONESCU, MS

STEFAN, RI

IOAN, I

ABOULENEIN, HY

机构：

[1] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT BIOL & MED RES,BIOANALYT & DRUG DEV LAB,RIYADH 11211,SAUDI ARABIA

[2] UNIV BUCHAREST,DEPT ANALYT CHEM,BUCHAREST 3,ROMANIA

[3] INST CHEM & PHARMACEUT RES BUCHAREST,BUCHAREST 3,ROMANIA

来源：

ANALYTICAL LETTERS | 1994年 / 27卷 / 09期

关键词：

MIANSERIN HYDROCHLORIDE; MIANSERIN PLASTIC MEMBRANE SENSOR; PHARMACEUTICAL ANALYSIS; POTENTIOMETRIC METHODS; CONTENT UNIFORMITY; DISSOLUTION RELEASE;

D O I：

10.1080/00032719408007424

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The construction and performance characteristics of ion-selective electrode for mianserin-drug cation, based on ion-pair complex with dinonylnaphthalenesulfphonate anion in a PVC matrix are described. The electrode shows a near-Nersntian response in the range 10(-2) - 5 x 10(-6) M drug concentration. Its selectivity relative to various cations is reported. The potentiometric methods are used to determine mianserin hydrochloride with good results. The electrode is also useful to the determination of content uniformity and dissolution-rate of uncoated mianserin tablets. The physical processes are numerically simulated by typical equations.

引用

页码：1647 / 1658

页数：12

共 25 条

[1] AMITRIPTYLINE-SELECTIVE PLASTIC MEMBRANE SENSORS AND THEIR PHARMACEUTICAL APPLICATIONS [J].

BUNACIU, AA ;

IONESCU, MS ;

PALIVAN, C ;

COSOFRET, VV .

ANALYST, 1991, 116 (03) :239-243

[2]

BUNACIU AA, IN PRESS INTEL INSTR

[3]

CHARSTENSEN JT, 1977, PHARM SOLIDS SOLID D

[4]

CHEN Z, 1985, APPLICATION ION SELE

[5]

Cosofret V.V., 1982, MEMBRANE ELECTRODES

[6] BISQUATERNARY-DRUG MEMBRANE ELECTRODES WITH HIGH-SENSITIVITY [J].

COSOFRET, VV ;

BUCK, RP .

ANALYTICA CHIMICA ACTA, 1984, 162 (AUG) :357-362

[7]

COSOFRET VV, 1984, ION SEL ELECTRODE R, V6, P59

[8]

COSOFRET VV, 1984, ANAL CHIM ACTA, V174, P299

[9]

COSOFRET VV, 1992, PHARM APPLICATIONS M

[10]

DALRUP T, 1982, CHROMATOGR NEWSL, V10, P1

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