ARSENIC-RELATED BOWENS-DISEASE AND PARAQUAT-RELATED SKIN CANCEROUS LESIONS SHOW NO DETECTABLE RAS AND P53 GENE ALTERATIONS

被引:26
作者
HSIEH, LL
CHEN, HJ
HSIEH, JT
JEE, SH
CHEN, GS
CHEN, CJ
机构
[1] NATL TAIWAN UNIV,DEPT DERMATOL,TAIPEI 10764,TAIWAN
[2] NATL TAIWAN UNIV,INST PUBL HLTH,TAIPEI 10764,TAIWAN
[3] KAOHSIUNG MED COLL,DEPT DERMATOL,KAOHSIUNG,TAIWAN
关键词
BOWENS DISEASE; RAS; P53; PCR-SSCP;
D O I
10.1016/0304-3835(94)90180-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have investigated point mutations of condons 12, 13, and 61 in H-, K-, and N-ras oncogenes as well as p53 tumour suppressor gene exon 5 through exon 9 by PCR-SSCP analysis in 26 skin biopsy tissues from 16 arsenic-related Bowen's disease patients and 6 skin samples from 4 paraquat manufacturing workers. No mutation was found. These results are different from findings with UV associated skin cancers. Interestingly,a silent change at condon 27 of H-ras in one allele was detected in all 4 paraquat manufacturing workers and in 2 of 16 arsenic-related Bowen's disease patients. It is likely that the molecular mechanisms involved in arsenic and paraquat induced skin cancers differ from sunlight-related skin maligancies.
引用
收藏
页码:59 / 65
页数:7
相关论文
共 24 条
[1]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[2]   THE MOLECULAR-GENETICS OF CANCER [J].
BISHOP, JM .
SCIENCE, 1987, 235 (4786) :305-311
[3]   ARSENIC IN DRINKING-WATER OF CITY OF ANTOFAGASTA - EPIDEMIOLOGICAL AND CLINICAL-STUDY BEFORE AND AFTER INSTALLATION OF A TREATMENT-PLANT [J].
BORGONO, JM ;
VICENT, P ;
VENTURINO, H ;
INFANTE, A .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1977, 19 (AUG) :103-105
[4]  
BOS JL, 1989, CANCER RES, V49, P4682
[5]  
BOWRA GT, 1982, BRIT J IND MED, V39, P76
[6]   A ROLE FOR SUNLIGHT IN SKIN-CANCER - UV-INDUCED P53 MUTATIONS IN SQUAMOUS-CELL CARCINOMA [J].
BRASH, DE ;
RUDOLPH, JA ;
SIMON, JA ;
LIN, A ;
MCKENNA, GJ ;
BADEN, HP ;
HALPERIN, AJ ;
PONTEN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10124-10128
[7]   P53 MUTATIONS ARE COMMON AND EARLY EVENTS THAT PRECEDE TUMOR INVASION IN SQUAMOUS-CELL NEOPLASIA OF THE SKIN [J].
CAMPBELL, C ;
QUINN, AG ;
RO, YS ;
ANGUS, B ;
REES, JL .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 100 (06) :746-748
[8]   CODON-12 HARVEY-RAS MUTATIONS ARE RARE EVENTS IN NONMELANOMA HUMAN SKIN-CANCER [J].
CAMPBELL, C ;
QUINN, AG ;
REES, JL .
BRITISH JOURNAL OF DERMATOLOGY, 1993, 128 (02) :111-114
[9]   COMPLETE NUCLEOTIDE-SEQUENCES OF THE T24 HUMAN BLADDER-CARCINOMA ONCOGENE AND ITS NORMAL HOMOLOG [J].
CAPON, DJ ;
CHEN, EY ;
LEVINSON, AD ;
SEEBURG, PH ;
GOEDDEL, DV .
NATURE, 1983, 302 (5903) :33-37
[10]   ONCOGENE ACTIVATION IN HUMAN BENIGN-TUMORS OF THE SKIN (KERATOACANTHOMAS) - IS HRAS INVOLVED IN DIFFERENTIATION AS WELL AS PROLIFERATION [J].
COROMINAS, M ;
KAMINO, H ;
LEON, J ;
PELLICER, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6372-6376