A BRIEF-HISTORY OF THE USE OF INTERFERONS AS TREATMENT OF MULTIPLE-SCLEROSIS

被引：50

作者：

JACOBS, L

JOHNSON, KP

机构：

[1] SUNY BUFFALO, DEPT NEUROL, BUFFALO, NY USA

[2] UNIV MARYLAND, DEPT NEUROL, BALTIMORE, MD USA

来源：

ARCHIVES OF NEUROLOGY | 1994年 / 51卷 / 12期

关键词：

D O I：

10.1001/archneur.1994.00540240089022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Interferons (IFNs) are a family of glycoproteins that are naturally secreted by certain cells in response to viral infection. The naturally occurring IFNs confer protection on other cells, preventing them from becoming infected, a phenomenon referred to as “virus interference” by Isaacs and Lindenmann1 in the first description of these proteins. In addition to their antiviral properties, the IFNs also have complex immunomodulatory, antiproliferative, and hormonelike activities, which are not completely understood.24. © 1994 Arch Neurol All rights reserved.

引用

页码：1245 / 1252

页数：8

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