VASCULAR-PERMEABILITY FACTOR VASCULAR ENDOTHELIAL GROWTH-FACTOR - AN IMPORTANT MEDIATOR OF ANGIOGENESIS IN MALIGNANCY AND INFLAMMATION

被引：283

作者：

DVORAK, HF ^{[1
]}

DETMAR, M ^{[1
]}

CLAFFEY, KP ^{[1
]}

NAGY, JA ^{[1
]}

VANDEWATER, L ^{[1
]}

SENGER, DR ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02215

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

ANGIOGENESIS; VASCULAR PERMEABILITY FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR; TUMORS; CHRONIC INFLAMMATION; PSORIASIS; RHEUMATOID ARTHRITIS; DELAYED HYPERSENSITIVITY; CYTOKINES;

D O I：

10.1159/000236988

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a multifunctional cytokine that is overexpressed in many transplantable animal and autochtonous human cancers, in healing wounds, and in chronic inflammatory disorders such as psoriasis and rheumatoid arthritis. All of these entities are characterized by angiogenesis, altered extracellular matrix, and variable degrees of hypoxia. In addition, two VPF/VEGF receptors, flt-1 and kdr, are overexpressed by endothelial cells that line the microvessels that supply these tumors/inflammatory reactions. On the basis of these and other data, we have proposed a model of angiogenesis in which VPF/VEGF plays a central role; this model is applicable to tumors and also to the angiogenesis that occurs in nonneoplastic processes.

引用

页码：233 / 235

页数：3

共 18 条

[1] VASCULAR-PERMEABILITY FACTOR (VASCULAR ENDOTHELIAL GROWTH-FACTOR) GENE IS EXPRESSED DIFFERENTIALLY IN NORMAL-TISSUES, MACROPHAGES, AND TUMORS [J].