MICRODIALYSIS SAMPLING COUPLED ONLINE TO FAST MICROBORE LIQUID-CHROMATOGRAPHY

被引：44

作者：

CHEN, AQ

LUNTE, CE

机构：

[1] UNIV KANSAS,DEPT CHEM,LAWRENCE,KS 66045

[2] UNIV KANSAS,CTR BIOANALYT RES,LAWRENCE,KS 66045

来源：

JOURNAL OF CHROMATOGRAPHY A | 1995年 / 691卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)00634-L

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A system which combines intravenous microdialysis sampling on-line with fast microbore liquid chromatographic analysis is described. Using a 14 mm x 1 mm I.D. ODS column, caffeine, theobromine and paraxanthine could be resolved in under 1 min and acetaminophen and its two main metabolites, the glucuronide and sulfate conjugates, could be resolved in 30 s. This fast separation allowed on-line microdialysis sampling to be conducted with a 1-min sampling interval. The system was evaluated by monitoring the pharmacokinetics following intravenous administration of acetaminophen and caffeine.

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页码：29 / 35

页数：7

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