LEUKOCYTE HEXOKINASE-ACTIVITY IN AGING AND ALZHEIMER-DISEASE

被引：4

作者：

ANTUONO, PG

RAVANELLIMEYER, J

NICHOLSON, K

BLOOM, AS

机构：

[1] MED COLL WISCONSIN,DEPT PHARMACOL & TOXICOL,MILWAUKEE,WI 53226

[2] DEPT VET AFFAIRS,MILWAUKEE,WI

来源：

DEMENTIA | 1995年 / 6卷 / 04期

关键词：

ALZHEIMER DISEASE; HEXOKINASE; LEUKOCYTES; ENERGY METABOLISM; CLINICAL MARKER;

D O I：

10.1159/000106947

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We determined the effects of clinical variables on hexokinase (HK) activity in leukocytes from Alzheimer's disease (AD) patients and controls. Age accounted for 51% of the variance in HK activity in the young and 23% in the old. Duration of illness in both familial and sporadic AD accounted for HK levels by 32 and 38%, respectively. Hexokinase activity increases with age and does not discriminate between familial and sporadic AD.

引用

页码：200 / 204

页数：5

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