EFFECT OF CHIRALITY ON SEROTONIN RECEPTOR AFFINITY

被引：15

作者：

GLENNON, RA

机构：

[1] Department of Pharmaceutical Chemistry School, Pharmacy Medical College, Virginia Virginia Commonwealth University Richmond

来源：

LIFE SCIENCES | 1979年 / 24卷 / 16期

关键词：

D O I：

10.1016/0024-3205(79)90032-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

α-Methylation of phenethylamines or tryptamine appears to have very little effect on serotonin (5-HT) receptor affinity when racemates are examined. Examination of resolved materials, using an isolated rat stomach fundus preparation, reveals that the R-isomers of DOM and MDA and the S-isomer of α-methlytryptamine possess a higher 5-HT receptor affinity than do their enantiomers. While S(+)-DOB possesses a lower affinity than its racemate, R(-)-DOB produces an appreciable agonistic response which interferes with the measurement of pA2 values. © 1979.

引用

页码：1487 / 1492

页数：6

共 15 条

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