DETERMINATION OF GUANFACINE IN BIOLOGICAL-FLUIDS BY ELECTRON-CAPTURE GLC

被引：16

作者：

GUERRET, M ^{[1
]}

LAVENE, D ^{[1
]}

LONGCHAMPT, J ^{[1
]}

KIGER, JL ^{[1
]}

机构：

[1] SANDOZ LABS,CTR RECH PHARMACOCINET,14 BLVD RICHELIEU,F-92505 RUEIL MALMAISON,FRANCE

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 02期

关键词：

Antihypertensive agents; potential—guanfacine; GLC analysis in plasma and urine; GLC—analysis; guanfacine in plasma and urine; Guanfacine—GLC analysis in plasma and urine;

D O I：

10.1002/jps.2600680225

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A quantitative electron‐capture GLC method with good sensitivity is described for the determination of guanfacine in human plasma and urine. By condensing its amidino group with hexafluoroacetylacetone, guanfacine is converted to a pyrimidino derivative with better GLC properties than the parent drug. This method allows the determination of guanfacine in plasma and urine at concentrations as low as 0.5 ng/ml and was applied successfully to measurement of plasma levels in humans after therapeutic dosing. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：219 / 221

页数：3

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