THE HYPOTHETICAL ACTIVE-SITE LATTICE - INVITRO AND INVIVO EXPLORATIONS USING A 3-DIMENSIONAL QSAR TECHNIQUE

被引：15

作者：

DOWEYKO, AM

机构：

[1] CIBA-GEIGY Corporation, Environmental Health Center, Farmington, 06032, CT

来源：

JOURNAL OF MATHEMATICAL CHEMISTRY | 1991年 / 7卷 / 1-4期

关键词：

D O I：

10.1007/BF01200827

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel three-dimensional QSAR technique (HASL) is described. HASL (Hypothetical Active Site Lattice) represents a composite description of a macromolecular binding site obtained from ligand molecule structures and activities. The scope and limitations of the method are discussed by means of its application to in vitro and in vivo data.

引用

页码：273 / 285

页数：13

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